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Leonard Simms seem like a key character to me. While we all know Hurley got the numbers from Leonard I feel it is more poignent that he then references the opening of the box.

Dialouge with Leonard

HURLEY: Is that why you're here, Lenny? 'Cause of the numbers? Did they do something to you? 'Cause I think they did something to me. I think it turned me into a jinx. Bad news to everyone around me. And when I tell people I think I'm the cause, they -- they -- they look at me like I'm nuts. They don't believe me. But I know. Ever since I won the lottery with those numbers.

(Leonard looks clearly at Hurley; he stops grunting.)

LEONARD SIMMS: You used those numbers to play the l-lottery?

(uh, oh.)

HURLEY: Uh ... yeah.

LEONARD SIMMS: You shouldn't have done that. (shouts) You've opened the box!

HURLEY: I what?

(Leonard pushes his chair out and stands up.)

LEONARD SIMMS: (shouting) You shouldn't have used the numbers!

HURLEY: Why not?

LEONARD SIMMS: (shouts) It doesn't stop! You got to get away from those numbers! You got to get far, far away! Do you hear me?!

(An Orderly appears and grabs Leonard.)

ORDERLY: All right, hey. Hey. Whoa, whoa, slow down.

LEONARD SIMMS: Oh, don't you understand?! You got to get away from them or it won't stop!

ORDERLY: Len-Lenny. Try and calm down.

(Hurley gets to his feet.)

HURLEY: Wait a sec, wait a sec. I need some answers.

(The Orderly pushes Hurley aside.)

ORDERLY: Sir, sir. You need to step away.

(The Orderly grabs Lenny and guides him toward the door.)

HURLEY: Lenny, the numbers! Where'd you get them?

LEONARD SIMMS: (shouts over his shoulder) Sam Toomey! He heard them!

HURLEY: Who's Sam Toomey?

LEONARD SIMMS: He heard them in Kalgoorlie.

HURLEY: What's Kalgoorlie?

Dialouge with Martha

HURLEY: Anyway ... he told me about Sam ... hearing something.

MARTHA TOOMEY: Oh. You're talking about the numbers.

HURLEY: Yes. The numbers. Exactly. Do you know anything about them?

MARTHA TOOMEY: Sam and Leonard were stationed at a listening post monitoring long wave transmissions over the pacific. Boring job. Sam hated it. Nothing to do but listen to static night after night -- till one night, back sixteen years ago, there's something in the static. A voice cuts through -- a voice repeating those number over and over again.

(Mesmerized, Hurley nearly drops his tea cup. He catches himself and the tea cup clinks against the saucer.)

MARTHA TOOMEY: Couple of days later, we're at the fair in Kalgoorlie, and some Wally there's got this jar. Must have been big as a pony, and it's filled to the rim with beans. Filly's offering fifty grand to anyone able to guess how many beans are in that jar within ten.

HURLEY: Sam used the numbers.

MARTHA TOOMEY: Yep. The answer was exact to the bean. Man had been running the same scam for forty years. Nobody'd ever come close. (She shrugs.) So we won the money. On the way home, a pickup truck blows a tire on the highway, hits us head-on. Lost my leg that night.

The Number

The Sri Lanka video tells us that the number the core environmental and human factors that make up the Valenzetti equation. We also now know that the Island has been set up for the DHARMA project and has a radio transmitter broadcasting the numbers on an encrypted frequency (I assuming longwave for now) that would be monitored by the HANSO Foundation. I am inferring that if the the scientist were successful that the transmission would change at least one of the number to signify success.

Optimal Expediency

We are told that the island will allow the scientist to work with optimal expediancy. More recently it was pointed out to us that we have a very basic assumption about time on the island. We believe them to have been there about 65 days and yet 2 yrs have past. Now, if their time is going slower that is hardly 'optimal expediency' you would think the opposite would be true. The scientist would be more efficient if they had 2 yrs of time for our 65 days! Perhaps this change in this condition is related the the incident and lead to closing of the DHARMA project since they would have no chance of finding the solution in this new time scale.