From Lostpedia
There are many locations from Season One, Season Two, and Season Three, of Lost that are featured in Lost: Via Domus.
On The Island
Main article: the Island
DHARMA Initiative stations
The Hatch (The Swan exterior)
Episodes: "Fourty-Two"
Info: The unopened hatch is seen by Elliott in the third episode of the game. A beam of light can be seen omitting from the window. As Elliot investigates the hatch, he can photograph the numbers 4, 8, 15, 16, 23, 42 etched on the side.
The Swan
Episodes: "Fourty-Two", "Hotel Persephone"
Info: The Swan contains three electrical panels. Fuses must be placed in the correct sequence in order for the lockdown to end. During the lockdown in episode four, Elliott discovers the blast door map and a second map leading to the incident room.
The Staff
Episodes: "Fourty-Two"
Info: In order to go to the Staff medical station, Elliott must view six different objects at the beach camp (each with one of the numbers 4, 8, 15, 16, 23, 42) in correct sequence in order to be transported to the Staff. Two Apollo bars can be found: one in the nursery, and one in the operating room.
The Incident Room
Episodes: "Hotel Persephone"
Info: Across from the main entrance to the Swan Elliot finds a hidden room. Inside of this room is a huge magnetic reactor, which has fallen into complete disarray. Elliott can use the computer in the room to disable to reactor.
The Flame
Episodes: "Whatever It Takes"
Info: Elliott enters the Flame through a secret back entrance, located across the Sonar fence. The basement of the Flame is dark, so Elliott must have a lantern or torch in order to navigate. In the upper level of the Flame, Elliott encounters Mikhail and Beady Eyes.
Losties' Locations
Caves
Episodes: "A New Day", "Via Domus"
Info: Elliott must navigate through two different caves, in episode two and three. The first cave leads to the front section of the plane. The second cave leads to the compass that has Via Domus inscribed in it.
Miscellaneous Island locations
Jungle
Episodes: Lost: Via Domus
Info: The jungle is full of dangers, especially the Dark Territory. There are many Others patrolling the jungle in lookout points in the trees. They will not hesitate to shoot Elliott if he is in shooting range. The Monster frequently stalks Elliott in the jungle. The banyan trees are a great place to hide from the Monster and the Others.
River
Episodes: "Via Domus"
Info: Elliott and Locke go to the caves in episode three. On their way, they cross a bridge over a river with a waterfall.
Sonar fence
Episodes: "Whatever It Takes"
Info: Elliot flees the monster and ends up trapped between it and the sonar fence. After the monster scans Elliot, Juliet interrogates Elliot, then turns off the fence to let him through.
Off the Island
Main article: World Locations
Recurrent & Important location
Rico's shop
Episodes: "Via Domus", "Fourty-Two"
Info: Lisa asks Rico for help in stopping Savo's actions, but Rico is being paid more by Elliot to keep information from her.
Countries
Thailand
Episodes: "A New Day"
Info: On the beach, Elliot shares a nice memory with Lisa.